Pellets Granules

Product Details:

We are offering high quality of Itraconazole Powder Pellets. We are known for manufacturing, exporting, distributing, trading and supplying Itraconazole Powder Pellets in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Itraconazole Powder Pellets in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Itraconazole Powder Pellets. Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Itraconazole Powder Pellets  as well as Intermediates of Itraconazole Powder Pellets is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Itraconazole Powder Pellets to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

Itraconazole Powder Pellets are commonly used in the pharmaceutical industry for oral drug delivery. The pellets are a dosage form designed to provide controlled release of the active pharmaceutical ingredient (API), itraconazole, which is an antifungal agent.

Here are the general technical details of Itraconazole Powder Pellets:

1. Active Pharmaceutical Ingredient (API):

Itraconazole: A broad-spectrum triazole antifungal agent used for treating fungal infections like candidiasis, aspergillosis, and dermatophyte infections.

Chemical formula: C35H38Cl2N8O4

Molecular weight: 705.64 g/mol

Solubility: Poorly soluble in water; solubility can be enhanced in formulations, often with the use of cyclodextrins or other solubilizers.

2. Pellet Characteristics:

Size: Pellets typically range in size from 0.5 mm to 2 mm in diameter, depending on the specific formulation and manufacturing process.

Shape: Spherical or cylindrical.

Coating: Pellets are often coated to protect the API from degradation and to control the release rate. The coating might include polymers or enteric coatings, depending on the intended drug release profile (immediate release, controlled release, or delayed release).

3. Formulation Components:

Itraconazole: The active ingredient.

Excipients:

Binders: Such as hydroxypropyl methylcellulose (HPMC), which helps to hold the pellet together.

Fillers/Carriers: Such as lactose, microcrystalline cellulose (MCC), or sugar spheres.

Disintegrants: Such as croscarmellose sodium, which helps the pellet to break down in the gastrointestinal tract.

Lubricants: Such as magnesium stearate, to prevent sticking during the pelletization process.

Polymers: For controlled-release formulations (e.g., ethylcellulose or polymethacrylate).

4. Manufacturing Process:

Powder Pellets Production:

Wet Granulation: Powder mixtures of itraconazole and excipients are moistened, granulated, and shaped into pellets.

Extrusion and Spheronization: In some cases, the wet granules are extruded into cylindrical shapes and then spheronized (rounded) to form uniform pellets.

Coating: Pellets are coated with polymers or other materials to modify release rates or protect the API.

6. Storage:

 

Itraconazole powder pellets should be stored in a cool, dry place, typically between 15°C to 25°C.

 

Additional Information:

• Pay Mode Terms: L/C (Letter of Credit),T/T (Bank Transfer),D/P,D/A
• Port of Dispatch: india
• Production Capacity: 1 mt
• Delivery Time: prompt
• Packaging Details: drum

Product Details:

We are offering high quality of Omeprazole Enteric Coated Pellets. We are known for manufacturing, exporting, distributing, trading and supplying Omeprazole Enteric Coated Pellets in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Omeprazole Enteric Coated Pellets in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Omeprazole Enteric Coated Pellets. Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who are manufacturing Omeprazole Enteric Coated Pellets as well as Intermediates of Omeprazole Enteric Coated Pellets.  

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently export Omeprazole Enteric Coated Pellets to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

1. General Information:Omeprazole enteric-coated pellets are a pharmaceutical formulation designed to deliver the active ingredient, omeprazole, in a controlled and effective manner. Omeprazole is a proton pump inhibitor (PPI) that reduces gastric acid secretion by selectively inhibiting the H⁺/K⁺ ATPase enzyme in the stomach lining.

2. Composition:Each pellet contains:Active Ingredient: Omeprazole (as enteric-coated granules)

Excipients: Sugar spheres (as a core for drug layering), Microcrystalline cellulose, Hydroxypropyl methylcellulose (HPMC), Sodium lauryl sulfate, Disodium phosphate, Mannitol, Talc, Magnesium stearate, Enteric coating polymers such as Methacrylic acid copolymer (Eudragit L or S), Triethyl citrate

Titanium dioxide (colorant)

3. Formulation & Structure:Omeprazole pellets are small, spherical or irregularly shaped granules, typically white or off-white in color. They are coated with an enteric polymer layer that protects the drug from degradation in the acidic environment of the stomach.

4. Mechanism of Action:Omeprazole is a prodrug that becomes active in the acidic pH of the parietal cells in the stomach.

It binds irreversibly to the H⁺/K⁺ ATPase (proton pump), preventing the final step of acid secretion.

5. Indications:Omeprazole enteric-coated pellets are used for: Gastroesophageal reflux disease (GERD), Peptic ulcers (gastric and duodenal), Zollinger-Ellison syndrome, Erosive esophagitis

6. Dosage Forms & Strengths:Omeprazole enteric-coated pellets are commonly formulated into:Capsules (delayed-release), Dispersible tablets, Sachets.Typical strengths: 10 mg, 20 mg, 40 mg per dosage unit.

7. Advantages of Enteric-Coated Pellets:Acid resistance: Prevents premature drug degradation in the stomach.Controlled release: Ensures the drug reaches the intestines for proper absorption.

Improved patient compliance: Reduced side effects like nausea compared to immediate-release forms.

8. Storage Conditions:Store below 25°C (77°F), Protect from moisture and direct sunlight

Keep in an airtight container

9. Side Effects:Nausea, vomiting, Headache, Diarrhea or constipation, Abdominal pain, Long-term use may lead to vitamin B12 deficiency, bone fractures, or hypomagnesemia.

10. Special Precautions:Should not be crushed or chewed to maintain the enteric coating.

Should be taken before meals for maximum efficacy.Long-term use requires monitoring for osteoporosis and kidney issues

Additional Information:

• Item Code: 0781-2234-01
• Pay Mode Terms: L/C (Letter of Credit),T/T (Bank Transfer),D/P,D/A
• Port of Dispatch: india
• Production Capacity: 5000 MT per month
• Delivery Time: prompt
• Packaging Details: 25kgs drum

Product Details:

We are offering high quality of Pantoprazole EC Pellets. We are known for manufacturing, exporting, distributing, trading and supplying Pantoprazole EC Pellets in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.

Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Pantoprazole EC Pellets in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.

Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Pantoprazole EC Pellets. Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who are manufacturing Pantoprazole EC Pellets as well as Intermediates of Pantoprazole EC Pellets.  

Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.

Shreeji Pharma International currently exports Pantoprazole EC Pellets to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.

1. General Information:

Pantoprazole EC (Enteric-Coated) Pellets are a pharmaceutical formulation designed for the delayed release of pantoprazole sodium, a proton pump inhibitor (PPI).

2. Composition: Pantoprazole EC pellets contain: Active Ingredient: Pantoprazole sodium sesquihydrate (equivalent to pantoprazole), Excipients: Microcrystalline cellulose, Mannitol, Hydroxypropyl cellulose, Hypromellose, Methacrylic acid copolymer (for enteric coating), Talc, Titanium dioxide, Triethyl citrate

3. Mechanism of Action: Pantoprazole belongs to the proton pump inhibitor (PPI) class and works by irreversibly inhibiting the H⁺/K⁺ ATPase enzyme in the gastric parietal cells.

4. Enteric Coating Purpose: The enteric coating ensures that pantoprazole bypasses the acidic environment of the stomach and is absorbed in the small intestine, where the pH is higher.

5. Pharmacokinetics: Absorption: Rapid but delayed due to the enteric coating; peak plasma levels are reached in 2-3 hours. Bioavailability: ~77% after a single dose.

Half-life: ~1 hour, but the acid suppression effect lasts 24 hours due to irreversible enzyme inhibition., Metabolism: Primarily metabolized in the liver (CYP2C19 and CYP3A4 enzymes).

6. Indications: Pantoprazole EC Pellets are used for: Gastroesophageal reflux disease (GERD), Erosive esophagitis, Helicobacter pylori eradication (as part of triple therapy), Peptic ulcer disease (PUD), Zollinger-Ellison syndrome (hypersecretory condition)

7. Dosage Forms & Strengths: Pantoprazole EC pellets are typically encapsulated in hard gelatin capsules or sachets for oral suspension. Common strengths include: 20 mg, 40 mg

8. Administration Guidelines: Should be taken 30-60 minutes before meals (preferably in the morning)., Swallow whole; do not chew or crush (as the enteric coating protects it from stomach acid).

9. Side Effects: Common: Headache, Nausea, Diarrhea, Abdominal pain, Flatulence

Rare but serious: Vitamin B12 deficiency (long-term use), Hypomagnesemia

10. Drug Interactions: Reduces absorption of drugs requiring acidic pH (e.g., ketoconazole, itraconazole).

 

11. Storage Conditions: Store at 25°C (77°F) with protection from moisture and heat.

Additional Information:

• Production Capacity: 5 mt per month
• Delivery Time: prompt
• Packaging Details: 25kg drum

Product Details:

We are offering high quality of  Rabeprazole EC Pellets We are known for manufacturing, exporting, distributing, trading and supplying  Rabeprazole EC Pellets in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier of  Rabeprazole EC Pellets  in Gujarat. India. Shreeji Pharma International manufacturing & supplying all products under GMP site with all types of regulatory supports.Shreeji Pharma International is the largest manufacturer, Exporter and supplier of  Rabeprazole EC Pellets .Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing  Rabeprazole EC Pellets as well as Intermediates of  Rabeprazole EC PelletsShreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years. Shreeji Pharma International currently export Rabeprazole EC Pelletsto countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAMcountries, Central American Countries and in European countries

Technical Specifications

Form                  - Granules

Color                  - white

Pharmacopoeial Status- BP / USP / EP

CAS Number     - 73590-58-6

Purity                  -    99

Assay                -    99

Introduction of product::The rabeprazole sodium enteric-coated pellet successively comprises a blank pellet core, a drug-containing layer, an insulation layer and an enteric-coated layer from the inside to the outside. The drug-containing layer comprises Rabeprazole sodium, an adhesive and a pH conditioning agent.

How does it work::Enteric coating is a useful strategy for the oral delivery of drugs like insulin which rapidly degrade in the stomach, as it prevents the drug being released in the acidic conditions of the stomach before reaching the intestine

Applications. Or where it is used::Uses Rabeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers).

Dosage of usage ::Adult dosage (ages 18 years and older)Typical dosage: 20 mg once daily.The length of treatment depends on your condition. It will be different if you have acid-related damage in your esophagus, or if you’re only being treated for heartburn symptoms caused by GERD.

Side effects : headache,pain in the abdomen (stomach area),sore throat,gas,infection,constipation,diarrhea

Warnings and precautions while using this product

For people with liver problems: If you have liver problems or a history of liver disease, you may not be able to clear this drug from your body well. This may increase the levels of rabeprazole in your body and cause more side effects. If you have severe liver disease, talk with your doctor about whether this drug is safe for you.

Additional Information:

• Production Capacity: 5000 mt per month
• Delivery Time: prompt
• Packaging Details: 25kgs drum pack

Product Details:

We are offering high quality of ESOMEPRAZOLE PELLETS POWDER . We are known for manufacturing, exporting, distributing, trading and supplying ESOMEPRAZOLE PELLETS POWDER   in in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.
Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier ESOMEPRAZOLE PELLETS POWDER   in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.
Shreeji Pharma International is the largest manufacturer, Exporter and supplier of ESOMEPRAZOLE PELLETS POWDER . Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing ESOMEPRAZOLE PELLETS POWDER  as well as Intermediates of ESOMEPRAZOLE PELLETS POWDER .  
Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.
Shreeji Pharma International currently export ESOMEPRAZOLE PELLETS POWDER  to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.
 
Esomeprazole Pellets Powder is a form of Esomeprazole, which is a proton pump inhibitor (PPI). This medication is used to reduce stomach acid production, helping to treat conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related disorders. The pellet formulation is designed for easier delivery and controlled release of the drug over time, offering the potential for better efficacy and patient compliance.
Here’s a detailed description of Esomeprazole Pellets Powder:
Chemical Name:
Esomeprazole.
Molecular Formula:
C17H18N3O3S (for the active ingredient Esomeprazole).
Chemical Structure:
Esomeprazole is the S-isomer of omeprazole. It works by selectively inhibiting the H+/K+ ATPase enzyme (proton pump) in the stomach, thereby reducing gastric acid secretion.
Appearance:
Esomeprazole Pellets Powder typically appears as a white to off-white crystalline powder containing tiny pellets that are coated with a protective layer. The pellets are designed to withstand stomach acid, allowing the medication to be released in the small intestine for optimal absorption and effectiveness.
 Esomeprazole pellets powder is used for the treatment of the following conditions:
Gastroesophageal Reflux Disease (GERD): It helps manage symptoms such as heartburn, regurgitation, and acid reflux. It is also used to heal erosive esophagitis caused by acid reflux.
Peptic Ulcers: Used to treat gastric ulcers and duodenal ulcers.
Helicobacter pylori Eradication: Esomeprazole is used in combination with antibiotics to eradicate H. pylori, a bacterium associated with peptic ulcers.
Dosage and Administration:
Esomeprazole Pellets are usually encapsulated in gelatin capsules or, in some cases, administered as a reconstituted suspension.
Side Effects:
Common side effects of Esomeprazole Pellets Powder include:
Gastrointestinal Issues: Diarrhea, nausea, constipation, and flatulence.
Precautions:
Liver Disease: Esomeprazole should be used cautiously in patients with liver disease, as it is metabolized in the liver. Dose adjustments may be necessary in such cases.
Bone Health: Long-term use should be monitored for signs of bone-related issues, such as osteoporosis or fractures.
Storage:
Esomeprazole Pellets Powder should be stored in a cool, dry place, typically at room temperature (20°C to 25°C).
The medication should be kept in an airtight container and protected from moisture and heat.

Additional Information:

• Item Code: 119141-88-7
• Pay Mode Terms: L/C (Letter of Credit),T/T (Bank Transfer)
• Port of Dispatch: india
• Production Capacity: 5 mt
• Delivery Time: prompt
• Packaging Details: 25 kgs